Betts went deep twice off Orioles starter Kevin Gausman, including a leadoff shot, and then again off reliever Dylan Bundy in the seventh. He became the first Red Sox player with a three-homer game since Will Middlebrooks on April 7, 2013. Betts is also the first Red Sox leadoff hitter to go deep three times in one game.
Dustin Pedroia followed Betts' first homer with another off Gausman, who has allowed three homers in back-to-back starts.