The last time Indiana beat Ohio State on a football field, none of the current players on either team were alive. But the Hoosiers, who have lost 20 times in a row to the Buckeyes, are 4-0 against the spread over the last four meetings. Indiana takes its shot at the defending national champs Saturday afternoon in Bloomington.
Point spread: Buckeyes opened as 17.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 43.9-24.1 Buckeyes
Why the Ohio State Buckeyes can cover the spread
OSU is off to a 4-0 start to this season after beating Western Michigan last week 38-12.