It doesn't come up very often, but Ohio State is 3-1 both straight up and against the spread in games following losses under head coach Urban Meyer. Coming off a shocking upset loss at Penn State last week, the Buckeyes might have fire coming out of their ears when they host Northwestern on Saturday afternoon at the Horseshoe.
Point spread: The Buckeyes opened as 24-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 43.5-15.0 Buckeyes (College football picks on every game)
Why the Northwestern Wildcats can cover the spread
Since a 1-3 start that included a loss to Illinois State, the Wildcats are 3-0 both SU and ATS, following last week's 24-14 victory/cover over Indiana.