Inflated spreads seem to be taking a toll on Ohio State, as the Buckeyes are 0-4 against the spread over their last four games and just 4-10 ATS over their last 14 home games.
Ohio State takes on another large number when it hosts Nebraska in a big game in the Big Ten on Saturday night at the Horseshoe in Columbus.
Point spread: The Buckeyes opened as 15.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 43.0-26.2 Buckeyes (College football picks on every game)
Why the Nebraska Cornhuskers can cover the spread
Nebraska was 7-0 until suffering a 23-17 overtime defeat at Wisconsin last week.