Since becoming Big 12 rivals West Virginia is 5-1 straight up and 4-1-1 against the spread in the series with Iowa State, with three wins in Ames. The Mountaineers are favored to make it four in a row at Jack Trice Stadium when they battle the Cyclones on Saturday evening.
College football point spread: The Mountaineers opened as 4.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 31.9-25.2 Mountaineers (College football picks on every game)
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