West Virginia lost its first meeting with new conference rival Oklahoma State after joining the Big 12 three seasons ago, but has beaten the Cowboys twice in a row since then, winning as a home dog and as road chalk. The Mountaineers will go off as home chalk when they host OSU Saturday afternoon for Homecoming in Morgantown.
Point spread: Mountaineers opened as six-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 26.5-22.2 Cowboys
Why the Oklahoma State Cowboys can cover the spread
Oklahoma State is 5-0, and 2-0 in Big 12 play, after nipping Kansas State last week 36-34 on a field goal with 30 seconds left.