The Oklahoma State Cowboys own the recent rivalry with the Iowa State Cyclones, winning the last five meetings outright. But Iowa State is 2-0 against the spread the last two meetings, keeping both games close as underdogs. The resurgent Cyclones will play as home dogs against the Cowboys on Saturday afternoon.
College football point spread: The Cowboys opened as 7-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 46.4-28.6 Cowboys (College football picks on every game)
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