Oklahoma owns the rivalry with Texas Tech, winning 17 of 23 meetings all time, including the last four in a row while going 3-1 against the spread. The Sooners will try to avoid the upset and stay unbeaten in Big 12 play when they visit Lubbock on Saturday night.
Point spread: The Sooners opened as 13-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 45-35.4, Sooners (college football picks on every game)
Why the Oklahoma Sooners can cover the spread
Following a 1-2 start to this season, Oklahoma has now won three games in a row, including a 38-17 decision over Kansas State last week.