Oklahoma beat Iowa State 18 times in a row into last season's meeting, and covered the spread the last four with blowouts. But the Cyclones pulled off one of the great shockers of last season, a 38-31 upset of the Sooners in Norman. Oklahoma seeks revenge when the teams meet for their Big 12 opener Saturday afternoon in Ames.
College football point spread: The Sooners opened as 17.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 36.0-14.8 Sooners (College football picks on every game)
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