The Houston Cougars exploded onto the national scene last year, winning 13 games and upsetting Florida State in a New Year's Eve bowl. Playing some good ball below the national radar for the last several seasons, the Cougars have piled up a 14-1-1 run against the spread as underdogs.
But the word is out on Houston, which opens the 2016 season against Oklahoma on Saturday afternoon at NRG Stadium.
Point spread: Sooners opened as 10-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 45.