Tonight is Game 1 of the 2022 NFL regular season, with the Buffalo Bills (-2.5)
taking on the reigning Super Bowl champion Los Angeles Rams (+2.5).
The Bills enter the season the favorites to be crowned champion at season’s end, with Draft Kings sportsbook placing them at +550 to win. The Rams are narrowly behind them, with the fifth-best odds (+1,200).
For the Bills, many are curious to see how they can handle the Rams’ passing attack with star cornerback Tre’Davious White on injured reserve. The Bills have to rely on younger cornerbacks to fend off wide receiver Cooper Kupp, including first-round pick Kaiir Elam and sixth-round selection Christian Benford.