Drew Brees, Saints (vs. 49ers): The 49ers defense struggled over the past two weeks against the Seahawks and Packers. Russell Wilson and Aaron Rodgers each had four passing touchdowns against them. Brees is coming off a four-touchdown performance against the Buccaneers. Look for him to keep the momentum going on Sunday.
Jared Goff, Rams (vs. Seahawks): The Seahawks are giving up the most passing yards per game and the most fantasy points to opposing quarterbacks.