After Mark Trumbo's two-out bloop single to right, Castillo sent Blue Jays reliever Jason Grilli's 1-2 pitch out of the park via left-center field to give Baltimore its second win in eight games. It marked the first run allowed in six appearances for Grilli.
The Blue Jays, who left the bases loaded in the seventh inning, had plenty of opportunities. They stranded eight men on base, and racked up four outs on failed bunt attempts.
The Orioles were down two runs in the sixth inning when Castillo's first two-run homer of the night -- which again scored Trumbo -- tied the game at 3.