Honda will leave Formula One to focus on zero-emission technology at the end of the 2021 season, leaving Red Bull and Alpha Tauri needing to find a new engine partner from that point onwards.
The decision was made at the end of September and the company does not intend to return to F1, Chief Executive Takahiro Hachigo said in an online news conference.
"This is not a result of the coronavirus pandemic but because of our longer-term carbon-free goal," he said.
Honda returned to F1 in 2015 in partnership with McLaren before switching to Toro Rosso in 2018 and joining forces with Red Bull in 2019.