1 p.m. ET | FOX
Matchup rating: 61.7 | Spread: SEA -2 (49)
What to watch for: Todd Gurley is expected to play a significant role as the Falcons' new top back. The team monitored his reps during training camp to make sure his left knee and body are fresh for the regular season. Although Gurley won't be asked to carry the full load, he could bring a much-needed run-game threat to what has been a pass-happy offense. -- Vaughn McClure
Bold prediction: Seahawks defensive back Marquise Blair will make a game-changing play.