Our panel of NFL Insiders predict Week 1's biggest upsets, fantasy flops and potential sleepers.
Plus: Which team will be the first to make a quarterback change? How will Odell Beckham Jr. fare against Jalen Ramsey? And which young quarterback would you start your franchise with?
What's your top upset pick for Week 1?
Matt Bowen, NFL writer: Chiefs (+3.5) over Chargers. I'll take the Chiefs on the road here given the offensive game plan I expect to see with Patrick Mahomes under center. Look for Andy Reid to dress this thing up, too.