Erik Lamela is the only injury absentee for Spurs, who are likely to be much-changed in keeping with Mauricio Pochettino's typical selection policy for domestic cup ties.
Michel Vorm, Moussa Sissoko, Harry Winks and Vincent Janssen are among the fringe players hoping to start.
There could be an Aston Villa debut in goal for loan signing Sam Johnstone, who has joined from Manchester United.
Mile Jedinak has overcome illness and should return in midfield.
MOTD COMMENTATOR'S NOTES
@SteveWilson1967: "When it comes to the FA Cup, Spurs and Villa are in with the elite.