Tottenham and Aston Villa stars Cristian Romero, Giovani Lo Celso, Emiliano Martinez and Emiliano Buendia face missing Premier League games next month after being included in Argentina's squad for their World Cup qualifiers.
Argentina is currently on the UK's 'red travel list,' meaning the four Premier League players will be forced to isolate for 10 days on their return from South America.
Lionel Scaloni's men face World Cup qualifying matches against Venezuela, Brazil and Bolivia on September 3, 5 and 10.
The Premier League games the four players could miss
TOTTENHAM
Crystal Palace A - September 11
Chelsea H - September 19
ASTON VILLA
Chelsea A - September 11
Everton H - September 18
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The news will come as a blow for Spurs and Villa as it means they will all certainly at least miss one Premier League match and likely be unavailable for another one on the following weekend.