Newcastle defender Fabian Schar has recovered from a hamstring injury.
A similar issue will keep Joe Willock out until after September's international break but new recruits Sandro Tonali, Harvey Barnes and Tino Livramento could make their debuts.
Aston Villa's Emi Buendia injured his cruciate ligament in training this week and may be out for eight months.
He joins Leander Dendoncker, Jhon Duran, Alex Moreno, Jacob Ramsey and Bertrand Traore on the sidelines.
Summer signings Pau Torres, Moussa Diaby and Youri Tielemans await their Villa debuts.
MATCH FACTS
Head-to-head
- Aston Villa are aiming to secure consecutive Premier League wins over Newcastle for the first time since the 2004-05 campaign.