Manchester City are again without injured defender Aymeric Laporte and forward Sergio Aguero, who misses his fourth game due to self-isolation.
Aston Villa head coach Dean Smith would not name which nine players had tested positive for Covid-19 during a recent outbreak, but said his team selection would be affected.
Ross Barkley could be involved after two months out with a hamstring injury.
LAWRO'S PREDICTION
A coronavirus outbreak at Aston Villa means their first team have not played since they went to Old Trafford on New Year's Day, which was the best part of three weeks ago.