Aston Villa remain without captain Jack Grealish for a 12th successive match, but he could return for their fixture with Everton on Thursday.
Manchester United manager Ole Gunnar Solskjaer reported that he has no new injury problems following their Europa League semi-final clash with Roma.
However, given that they are playing four times in just eight days, he will rotate his squad.
LAWRO'S PREDICTION
Following the second leg of their Europa League semi-final with Roma on Thursday, this is the second of four games in eight days for Manchester United.
But their squad is big enough to deal with that schedule and, other than their top two or three players - like Bruno Fernandes for example - the difference between their first and second choices in each position is not very big.