Arsenal centre-back David Luiz has been passed fit following neck spasms, while Mesut Ozil is under consideration after being left out last weekend against Fulham.
Defenders Shkodran Mustafi, Sokratis and Pablo Mari are among the absentees.
West Ham captain Mark Noble missed training on Friday with a toe injury and is being monitored.
Ex-Arsenal midfielder Jack Wilshere is a doubt to face his former club because of an ankle problem.
Record signing Sebastian Haller scored twice in the EFL Cup midweek and could be recalled.
LAWRO'S PREDICTION
Arsenal have been top of the league all week, which does not mean very much after only one game apart from the confidence you get from knowing you have made a really good start.