Arsenal head coach Mikel Arteta is confident Bukayo Saka and Gabriel Martinelli will be fit to play.
Goalkeeper David Raya is ineligible to face his parent club, while Oleksandr Zinchenko and Takehiro Tomiyasu are likely to remain out.
Ivan Toney is fit to start for Brentford, while Bryan Mbeumo could return from injury later this month.
Ethan Pinnock, Aaron Hickey, Kevin Schade, Rico Henry, Josh Dasilva and Ben Mee are still sidelined.
MATCH FACTS
Head-to-head
- Brentford's only win against Arsenal in the past 10 meetings was by 2-0 at home in their first Premier League encounter in August 2021 (D2, L7).