Brentford defender Nathan Collins is ruled out after injuring ankle ligaments playing for the Republic of Ireland.
The Bees are without number of other players, including Kevin Schade, Aaron Hickey, Ivan Toney and Rico Henry.
Arsenal goalkeeper Aaron Ramsdale will replace David Raya, who is on loan from Brentford and therefore ineligible, while Fabio Vieira is suspended.
Gabriel Jesus is available after making his return from injury with Brazil.
Manager Mikel Arteta hopes to welcome back captain Martin Odegaard, who is recovering from a concussion suffered in training.
Ben White will also be monitored but Emile Smith Rowe, Jurrien Timber and Thomas Partey are still unavailable.