Manchester United defender Alex Telles has tested positive for Covid-19 and so misses the game while he self-isolates.
Anthony Martial, who scored his first goal of the season against RB Leipzig on Thursday, serves the final match of a three-game ban.
Arsenal's David Luiz is set to miss out because of a thigh injury sustained during Sunday's defeat by Leicester.
Manager Mikel Arteta will bring back a host of first-team regulars who were rested for Thursday's win over Dundalk.
LAWRO'S PREDICTION
Arsenal defender David Luiz is out injured so I am not sure whether Gunners boss Mikel Arteta will stick with his system of playing three at the back without the Brazilian.