Neither Kevin de Bruyne nor Aymeric Laporte will travel to Leipzig for Wednesday night's crucial Champions League last 16 showdown with RB Leipzig.
Pep Guardiola is set to shuffle the pack but not including two of his most crucial stars for the trip to Germany, perhaps with an eye on Saturday's clash with Bournemouth in the title race.
The champions dropped two points on the road to Nottingham Forest on Saturday, allowing Arsenal to regain the lead with a two-point advantage over their rivals.
Unsurprisingly given his status in the game, De Bruyne has been a near ever-present for Guardiola's side, with 31 appearances.