Chelsea pair Mateo Kovacic and Andreas Christensen will both miss Wednesday's Premier League game but could be fit for the FA Cup final on Saturday.
There might be a senior debut for academy player Tino Livramento, who was an unused substitute on Saturday.
Granit Xhaka and Pablo Mari hope to be available for Arsenal after injuries but David Luiz is not in contention.
Emile Smith Rowe had to come off with a hamstring injury on Sunday and will be assessed.
MATCH FACTS
Head-to-head
- Arsenal won the reverse fixture 3-1 and could complete the league double over Chelsea for the first time since 2003-04.