Brighton defender Pervis Estupinan could return after being rested in the midweek draw with Brentford.
However, Kaoru Mitoma, Solly March, James Milner and Billy Gilmour remain out.
Arsenal's Bukayo Saka faces a late fitness test after missing Wednesday's 2-0 victory over Luton with a minor injury.
Midfielder Declan Rice could return to the starting line-up after coming on as a substitute against the Hatters.
The Gunners' only confirmed injury absentee is Jurrien Timber.
MATCH FACTS
Head-to-head
- Arsenal are unbeaten in their last three visits to Brighton (W2, D1).
- Each side has won five of the 13 Premier League matches between the sides.