Arsenal midfielder Kai Havertz is suspended after accumulating five yellow cards.
Takehiro Tomiyasu, Fabio Vieira, Thomas Partey and Jurrien Timber remain sidelined.
West Ham may need to monitor Nayef Aguerd, who missed the 2-0 victory against Manchester United through illness.
This game may come too soon for Michail Antonio, who is nearing a return from a knee injury.
MATCH FACTS
Head-to-head
- Arsenal have won 12 of their past 13 home league games against West Ham, with the exception being a 2-0 loss on the opening weekend of the 2015-16 season.