Arizona has been represented in the Major League Baseball All-Star Game by alums Trevor Hoffman, Kenny Lofton, Mark Melancon, Hank Leiber and Tony Clark. Hoffman leads all Arizona alums with seven appearances, Lofton had six, Melancon four, Leiber three and Clark one.
Hoffman is the only one of the five who is in the Hall of Fame. During his two seasons playing for Arizona, Hoffman was a shortstop. After selecting Hoffman in the 11th round of the 1989 Major League Baseball Draft, the Cincinnati Reds converted him to a pitcher.
Hoffman was 0-1 in seven all-star game appearances with a 6.