After Colorado had by far its worst 2025 defensive performance in a 53-7 loss at Utah last week, Arizona will have its opportunity against a vulnerable Buffaloes on Saturday in Boulder. Colorado allowed season highs of 422 rushing yards, 587 total yards and 7.72 yards per play at Utah.
Saturday will feature two of the four worst run defenses in the Big XII during October. Arizona allowed 490 rushing yards in its last two games and was 13th in the Big XII with opponents averaging 193.0 yards per game on the ground against the Wildcats in October.