As they have all season, Pro Football Focus releases some highlights for every game they grade. Their grades for the Arizona Cardinals show more or less what we saw on the field.
Their numbers say Lyle Sendlein and Ted Larsen struggled on the offensive line. Sendlein (-6.2) and Larsen (-6.5) both struggled greatly in this game, especially in pass blocking. This was by far Sendlein's worst pass protection game of the year.
The offensive line struggles were seen in the running game. David Johnson only rushed for 25 yards on 11 carries, but he gained 19 of those 25 yards after contact.