Anaheim regained sole possession of third place in the division, two points ahead of Los Angeles and Calgary. The Ducks are a point behind second-place San Jose.
Starting goalie John Gibson (22-15-6) stopped all 13 shots he saw for Anaheim, but was inadvertently clipped by Vegas' Reilly Smith behind the net with three seconds left in the second period and didn't return due to a lower-body injury.
The Ducks improved to 15-11-7 on the road this season and have won four of their last five games away from home. Anaheim became just the seventh team — and fifth in regulation — to win on Vegas' home ice.