The Ducks captain, who missed Friday's win with flu, earned assists on first-period goals from linemates Rickard Rakell and Corey Perry, and the Chicago Blackhawks never recovered.
Getzlaf added a third assist on Perry's second goal, and the Ducks topped the Blackhawks 6-3 on Sunday afternoon before 16,989 at Honda Center.
The chemistry is now evident, particularly when Rakell, Getzlaf and Perry are on the ice.
"Things are starting to click," said Getzlaf, whose 45 points rank second on the club, despite the fact he's missed 25 games. "Obviously as a group, it's nice to have our full lineup in, everybody going.