Six American Athletic Conference baseball teams picked up victories on the opening day of the 2025 season on Friday, February 14.
| February 14 | |||
|---|---|---|---|
| Away | Home | Location | Links |
| Northeastern 1 | Charlotte 6 | Charlotte, N.C. (Game 1) | Box Score |
| George Mason 7 | East Carolina 3 | Greenville, N.C. (Game 1) | Box Score |
| Southeast Missouri 1 | Memphis 4 | Memphis, Tenn. | |