The Clemson Tigers are 8-0 straight up in their last eight meetings with the Wake Forest Demon Deacons, but only 4-4 against the spread as the great equalizer has taken its toll.
The national champions face a three-touchdown spread for Saturday afternoon's homecoming date with the Deacons at Death Valley.
College football point spread: The Tigers opened as 23-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 42.7-20.4 Tigers (College football picks on every game)
Check out the OddsShark podcast on iTunes or at OddsShark.