Clemson owns six straight victories in the series with Wake Forest, going 4-2 against the spread in the process even while favored by some large numbers. The undefeated Tigers are favored by a bunch for Saturday afternoon's ACC match with the Demon Deacons at Death Valley.
Point spread: The Tigers opened as 29-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 45.0-12.2 Tigers
Why the Wake Forest Demon Deacons can cover the spread
Wake has lost four games in a row but covered the last two, after hanging with Notre Dame last week, losing 28-7 but covering 25 points.