Duke has been upset by an unranked ACC opponent for the second straight game after Notre Dame stunned the Blue Devils, 95-91, in an offensive shootout at Cameron Indoor Stadium.
The defending national champions were coming off a 68-63 loss against Clemson on Wednesday, their first conference loss of the season.
Duke's offense was mostly Luke Kennard (30 points), Brandon Ingram (25) and Grayson Allen (18). No one else reached double figures.
The Fighting Irish rode an 11-1 run to start the second half after going into the break down 50-45 to capture their first win over a ranked opponent this season.