Playing as one of the betting public's favorite teams, Duke is just 2-6-1 against the spread over its last nine games. The Blue Devils nearly blew a cover against Yale over the weekend, and will probably go off as underdogs when they meet Oregon in a West region Sweet 16 matchup Thursday night in Anaheim, California.
Point spread: The Ducks opened as two-point favorites; the total was 156.5, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
March Madness pick, via Odds Shark computer: 82.3-68.6 Ducks
Why pick Duke to cover the spread
The fourth-seeded Blue Devils, at-large invitees after going 12-8 in an ACC conference that sends six teams to the Sweet 16, reached the second weekend of this NCAA tournament by holding off UNC-Wilmington last Thursday 93-85, then doing the same to Yale Saturday 71-64.