Outfielder Rymer Liriano and left-hander Giovanni Soto were outrighted to Class AAA Charlotte after clearing waivers on Friday.
The moves put the White Sox 40-man roster at 36. The team is expected to add several players to that roster before finalizing the Opening Day roster on Sunday.
Liriano, 25, batted .170 with two homers and six RBIs in spring training.
Soto, 25, was 0-1 with a 3.86 ERA while appearing in two games for the White Sox in spring training.
The White Sox open the 2017 season at home against the Tigers on Apr. 4.