Daniel Descalso hit a three-run homer off White Sox right-hander Miguel Gonzalez to give the Diamondbacks a 3-1 lead Monday night at Chase Field.
Gonzalez pitched three scoreless innings before he gave up a single to Paul Goldschmidt and walked Chris Owings in the fourth. Descalso then hit his fourth homer of the year to center field.
Sox center fielder Leury Garcia put the Sox on the board with a solo home run to right field off Diamondbacks right-hander Zack Greinke in the fifth.