The Indianapolis Colts (+1)
(0-1) travel to take on the also winless Houston Texans (-1) (0-1) for an early AFC South clash. These two divisional rivals feature a pair of top rookie quarterbacks, the Colts’ Anthony Richardson (the 4th overall pick in the 2023 NFL Draft) and the Texans’ C.J. Stroud (the 2nd overall pick respectively)—although he’s currently listed as ‘questionable’ on the team’s injury report, but is expected to try to play before kickoff.
Not only do the Colts and Texans have new starting quarterbacks, but each has a new head coach, the Colts with Shane Steichen, and the Texans with DeMeco Ryans.