Manchester United captain Wayne Rooney should be available after missing the win at Leicester because of illness.
Defender Phil Jones could also return after sitting out the Leicester game with a bruised foot.
Watford's Christian Kabasele has recovered from a muscle problem and could feature.
However, the game is likely to come too early for Nordin Amrabat, who has returned to training after an ankle injury.
MOTD COMMENTATOR'S NOTES
Steve Bower: "I was at Vicarage Road back in September to see Watford's first-ever Premier League points against Manchester United, but Jose Mourinho's team have a much more solid and settled look about them now.