Yulieski Gurriel and Josh Reddick sparked Houston's fourth-inning rally with RBI hits before Gonzalez capped the rally with a two-run blast to left, his first home run of the spring. Marisnick belted his second Grapefruit League homer an inning earlier, a solo shot for Houston's first hit of the game.
Astros starter Joe Musgrove went five innings yielding just one run on four hits. The right-hander struck out four and walked one. He struck out the side in the second inning after falling behind 1-0 in the first inning on a double by Nats leadoff man Trea Turner and a Bryce Harper RBI sacrifice fly two batters later.