Mauricio Pochettino insisted Tottenham's temporary Wembley home was not a factor in Sunday's 2-1 Premier League loss to Chelsea.
Spurs are tenants of the national stadium this season as the construction of the new White Hart Lane is completed.
And in Wembley's first Premier League game Spurs were beaten. They have two wins in 11 games since the arena reopened in 2007.
"Wembley was not the problem," Spurs' head coach Pochettino said.
"I think the 'Wembley effect' is not the reason we lost the game.
"It doesn't affect me.