Anderson will be making his second start since being activated from the disabled list. He threw 75 pitches in his first start back, and he will have an increased pitch count this time out. He has never faced the Blue Jays.
Estrada has allowed more than three earned runs in just one of his last 13 starts and has a 2.42 ERA over that same span. The 32-year-old has been around for eight seasons, but this will mark his first career appearance against the Indians.