For the fourth time in five years, John Isner was bounced from the U.S. Open in the third round.
Isner, the world No. 21 and the second-highest ranked American, lost on Friday in four sets to Great Britain's Kyle Edmund. The big-serving North Carolina native hasn't made a U.S. Open quarterfinal since 2011.
For more on Isner's defeat and the rest of Friday evening's action—including Rafael Nadal's match against Andrey Kuznetsov—see our complete recap below.
For a look at Friday's day session, including victories by Americans Jack Sock and Madison Keys, check out SI.