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Pittsburgh Steelers vs. San Diego Chargers Betting Odds, Analysis, NFL Pick

San Diego is 5-1 against the spread in its last six appearances on Monday night, while Pittsburgh is 1-5 ATS over its last six Monday night appearances. A pair of 2-2 teams with playoff aspirations meet when the Chargers take on the Steelers Monday night out in sunny San Diego.

Point spread: Chargers opened as three-point favorites; the total was 46 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)

NFL pick, via Odds Shark computer: 29.1-18.0 Chargers

Why the Steelers can cover the spread

Pittsburgh is 2-2 this season, but 3-0-1 ATS, after falling in overtime last Thursday to Baltimore 23-20, but it's pushing the spread as a three-point underdog.