Week 4 might be the best time of the 2016 NFL season to pick upsets.
Upsets were the main storyline of last week, as favorites like the Carolina Panthers, New York Giants, Pittsburgh Steelers and New Orleans Saints took notable losses.
It should go without saying, but those who love underdogs had one heck of a week against the house.
Given some of the matchups and scenarios this week, it might be more of the same. Las Vegas will be more careful after getting burnt by the upsets last week, but bettors should welcome the challenge.