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Adam Wainwright has taken full responsibility for his rough start, but he's also optimistic things will turn around.

The right-hander hopes that begins Friday night when the visiting St. Louis Cardinals face the San Diego Padres.

Not since posting a 9.88 ERA while losing his first three starts of 2012 has Wainwright (0-2, 8.27 ERA) struggled this mightily to open a season.

"That's not the first time he's not been exactly where he wants to be," St. Louis manager Mike Matheny said. "He demands a lot of himself and he'll get it right.